Zimcor 40 (Simvastatin)
Used to reduce low-density lipoprotein-cholesterol, lipopretein band triglycerides and to increase high-density cholesterol in the treatment of hyperlipidaemias. Also used as adjunct treatment in patients with homozygous familial hypercholesterolaemia and is given prophylactically to hypercholesterolaemic patients with ischaemic heart disease.
Dosage and Administration
For patients with ischaemic heart disease - Adults: Initial dose of 20mg (1/2 tablet) in the evening. Dosage may be adjusted at intervals of not less than 4 weeks up to a maximum of 80mg (2 tablets) once daily in the evening.
For patients with homozygous familial hypercholesterilaemia - Adults: 40mg(1 tablet) once daily in the evening or 80mg daily in three divided doses:20mg, 20mg and 40mg (1 tablet) in the evening.
For patients taking ciclosporin, fibric acid derivatives or nicotinic acid - Adults: maximum dose of 10mg (1/4 tablet) daily. or as prescribed by a physician.